Shu'up Share definition Flag A contraction of the words "shut" and "up." Pronounced "Shuh-up!" Usually said by short chubby women or especially bitchy people. "Nuh-uh boi, you can't say dat!" "But I wasn't saying any-" "SHU'UP!" Shu'up by Kyothine April 22, 2009 0 0 Get merch Get the Shu'up mug. Buy Now — $32.95 See more merch