A person or organization that does things or operates in such a manner that is not in their best interest. This can be caused by a mental deficiency or some other psychological disorder. The sad reality is that this condition not only harms the individual or organization, but also everyone associated with that person or organization.
Urban Dictionary has been operating in a self destructive mode for many years by not instituting a plan for allowing its volunteer editors to vote to remove homophobic, racist and misogynist definitions that have been "already suggested for removal" but were kept because of the immaturity or mental deficiency of some of its editors. These horrific definitions are then allowed to remain on the UD web page for eternity with no way of removing them.
by PY Love and Peace November 30, 2012
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The act in destroying oneself with alcohol, drugs, sex, addictions, negative thoughts, setting yourself up for failure, Etc. The act of spiraling downward.
Have you seen Mike lately? He is totally being self-destructive. He has been on a 7-Day drinking binge.
by Jg979823 September 11, 2019
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Verb: to voluntarily destroy oneself, and/or any property under ones control, in order to deny any advantage to ones enemy(ies).
"As the Soviet Army surrounded the Stalingrad bunker, Hitler gave the order to Field Marshall von Paulus to self destruct, which he disobeyed."
by speedog May 3, 2010
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To position ones self so he is upside down, and jacks off until he cums. The result is a sloppy mess over his body and face, hence the self destruction. cumming sloppy mess cum jack off
I was home alone and decided to lay my legs up on my headboard and give myself a self destruction
by General Jovan March 17, 2007
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Synonym for a woman's monthly cycle wherein the lining of the uterine wall detaches itself resulting in a period.

Is a polite and non-gross euphemism for period.
"Jeez, someone's crabby."

"Well, I've got a self-destructing uterus, what do you expect?"
by ChristenMarie January 31, 2009
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1. A button in most mad scientists' lair that both blows up their crib and causes them to fall to their knees and yell, "NOOOOOOO!" while shaking their fists at the sky in a most hilarious manner.

2. Secondly, and more importantly, A song by Nine Inch Nails that was originally the first song on The Downward Spiral but now has three kickass remixes on Further Down The Spiral.
1. NOOOOOOOOOOO! Why did I even invent that button? Why did I give such a cutesy name and put it in such pain sight?? Damn you Mr. Self Destruct! Boom...

2. boom... boom. boom. (indecipherable whisper)
boom. boom.boom.boom.boomboomboomboomboom
I am the voice inside your head (and i control you). I am the lover in your bed (and i control you). I am the sex that you provide (and i control you). I am the hate you try to hide (and i control you).
by Fitoflaughter January 15, 2007
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The mechanical voice inside my head that controls me.
It takes me where I want to go, it gives me all I need to know, it lays me down it uses me up, Mr. Self Destruct
by TheKoromo-domo March 25, 2013
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