The branch of seduction guys use to score ass from girls quickly and efficiently.
"Yo man, I was running game on this chick all night and ended up taking her home."
by Orhan September 19, 2006
1. Picking up a girl (in some contexts guy, see 1a.) with the intent of using her for sex. Or in other words, using your game to run (on) a girl. It can also mean cheating on someone.

2. In a general context, running game means cheating or otherwise playing someone for a fool.
1a. 50 cent (Ya Don't Love Me) - Tryna run game on me you punk bitch, I know you don't love me.
1b. Jhene (Dog) - Tryin run game on me you're a dog - thinkin you could cheat on me
1c. Ciara (Pick Up the Phone) - run game on a rookie cuz I'm too sharp for that why, don't you pick up the phone?

2. Wu-tang (Shame on a nigga) - Shame on a nigga, who try to run game on a nigga...To the young youth, ya wanna get gun? Shoot!...Punk! You playing me, chump, you get DUMPED
by Gman3154 May 19, 2007
to run game on a shorty is to straight spit the ill flow in the dime pieces ear soo you can get up in that ass

to actively attempt to entice a lady...
or to hit on a girl yo?
mafucka: yo should i run game on that beotchhh
mafucka2: hell nah yo thats a dude you fuckin gay bitch
by dilloe December 31, 2004
Dealing a shit-ass fuck load of drugs to the point where you basically own that shit and nobody can compete with your hype shit
Ahh you need some blow dude? Haha I used to run the game back in the day, i got u
by 420swagyolo August 26, 2014
The Run Away Game, also knows as R.A.G for short, is when two people take a set of anal beeds and insert exactly half the beads into each person’s anus. Each person then stands Ass to Ass and clinches his or hers anus muscles as tight as they can.

When the word is given the two participants Run Away from each other attempting to retain more of the anal beads than the other.

The participant left with a tail of anal beads WINS !
"Hey would you like to go to Mesquite Nevada and play the Run Away Game and see who wins the tial".
by Jared MCSO January 10, 2013
to party hard. to be a boozehound a womanizer.
Anthony: hey, that kid Syno is an animal. he runs hard game.
by AntwanDages November 5, 2010
1: Derived from the Eminem song "Superman". Translates into: "Oh Yes, Young woman, continue those promiscuous actions."
For example, if a girl were to "shake her tail-feather," one might reply with... "Ewww yah gurl, run dat game."
by brian seward November 26, 2004