The spit that goes on a penis before insertion into a dry hole
Mike Tyson said he used prison lube when he had intercorse with that girl.
by Tracey September 5, 2003
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Warm spit and/or the shitty residue left in a man's anus after taking an extremely sticky shit.

Hey, Tyrone. Earl raped you using prison lube, you bitch nigga.
by Assex 776 August 30, 2007
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The blood and feces inmates naturally exude when larger inmates forcefully impale them in delicate areas, generally against their will.
Inmate 1: Heard you had to put your celly in his place last night. You didn't break him did you?

Inmate 2: Nah, he's just fine. He had plenty of prison lube in'em.
by Zen Chaos October 12, 2020
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