The altered mental state that accompanies acute illness or use of intoxicating substances. Usually a result of too many bevvies.
"I don't remember what happened last night, I was completely off my face."

"She got off her face and started slapping people."
by jessie4000 June 7, 2006
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running off my face generally describes how badly your nose runs while you have a cold or during allergy season.
charlotte: charles, my allergies are killing me today. the pollen count must be at least a million. my freaking nose is running off my face.

charles: here's a box of tissues, babygirl. dang, looks like you are gonna need em.
by sweetontweety7777 March 29, 2009
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