mfugly Share definition Flag a guy/girl who is too ugly to be called just plain ugly-and must be called mother fuckin ugly, an then shortened to mufugly. :D u see that mfugly asshole ova thur tryin to holla at u?! mfugly by she who knowz December 17, 2004 0 0 Get merch Get the mfugly mug. Buy Now — $32.95 See more merch