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Meddlesome Bitch 

A trampy bitch who spends too much time with someone's significant other as a co-worker or "friend" and is too ignorant to understand proper boundaries, therefore causing drama in said relationship.
"Is that meddlesome bitch still calling and texting your man all the time?"

"Yeah, she's so pathetic I'd almost feel sorry for her if she wasn't such an attention whore."
Meddlesome Bitch by Misspelledlife January 17, 2010

Most Meddlesome Beings 

A term to describe inter-dimensional trouble makers and unwell-wishers who are above and beyond the most meddlesome.

Usually toxic masc beings who are set on destroying the lives of humans.

Also the key ingredient of our new staple food: spaghettified interdimensional catdog-esque most meddlesome beings, akin to Menchi.
The most meddlesome beings have outdone themselves and I lay here on the verge of death as I type this, surrounded by the outcomes of several strings of misfortunes and never ending tales of woe and misery that he has nonchalantly signed me up to, taking it upon himself to perfect the art of meddling and thus further destroying my entire sad-excuse-for-a-life.

meddlement

Used as a replacement term for a person/group of people that can't actually 'manage' anything that matters: instead of focusing on what's important, they meddle.
Meddlement shows up and gives you busy work (diverting you from actual productivity) when you're trying to fix things. They bitched about something, though, so they earned their paycheck!
meddlement by mortis fugit January 17, 2014

Mettlesome 

Their horses were beasts of burden, not mettlesome chargers.

And Juliet’s mettlesome temper became the engine that fueled the drama, above all in Act III, in which she seldom leaves the stage.