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A mix of the street drug LSD and the chemical found in many over-the-counter cough medicines DXM used together to produce more profound psychedelic effects than would be if they were used alone.

The most 2 most common methods are: 1) To take the DXM first (by use of cough syrup, gel caps or sprays), wait until the effects of the drug are felt, then drop the acid OR 2) Take both at the same time. The LSD will be felt first and then 1-2hr the DXM will be felt.
mIRC chatter1: Man, I took some lsdxm for the first time an hour ago and HOLY SHIT I'm tripping cartoons here...

mIRC chatter2: Dude, your going to be tripping for HOURS, have fun ^_^
lsdxm by Neoluigi December 7, 2006
Words you can keep
The zone your moite reaches when his acid is on the downside of its peak. At this point in time his soul will recede into the darkness of his mind. No matter how you attempt to address your moite his only reaction will to produce an icy glare and a maniacal smile taking you deep into your childhood past, back to the horror of the clowns. Is he dead or just still? Once at the stage of LSDomez this being's only purpose appears to be performing intricate trolling of your equally unstable sanity. Yet, it soon becomes clear that once the point of LSDomez is reached, he has no more control over his face than you do over his multiversal shamanistic powers.
Metal: Dude, every time Gomez looks at that lamp it fuckin warms my obliques!
Andy: Fuckin LSDomez man he's going full cosmic!

Andy: Hey, have you seen Gomez?
Metal: He's right behind you man.
LSDomez: *Stares while lying on pool table*
Andy: Oh God! Its LSDomez! His ocular fixation is boring through my consciousness like an acid spear impaling a litmus brain!
Metal: Dude, take the shot and eat your ice cream sandwhich.
LSDomez: *stares from couch*
Andy: Alright
Metal: And stop making me elaborate your exclamations of 'shiiiit' through extended metaphors on colloquial dictionary websites to make the definition look cooler, just say it at the time.
Andy: Alright
LSDomez: *Stares from floor*
LSDomez by Metal-man August 28, 2010
Related Words
lsdxm LSDM Lsdmthc LSDomez
"Lying Sack of Dog Mess" // "Lying Sack of Dog Manure" -- a press spokesman or personality lying to listeners / users / public (abusing their platform within mainstream media).
Whoopi Goldberg (of "The View") called Glenn Beck of FOX NEWS (oxymoron check on the word "news") a LSDM for openly lying on-air about Whoopi Goldberg and Barbara Walters. Exposed by Whoopi Goldberg on May-20-2009 (youtube --watch?v=W2FK2vchoEo) and referenced in media (E.G. Crooksandliars dot com of same date)
LSDM by Ivan A. D'Mocracy May 21, 2009
A combination of lsd dmt and thc in one substance.
Last night we smoked lsdmthc.
Lsdmthc by Rushing pete (MENT) October 29, 2021
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