lesbiano Share definition Flag a masculine woman who is a homosexual, often known as a dyke. (versus lesbiana) "Ultimately, Rosie is a loser and a lesbiano, and ultimately ("The View") will fail because of Rosie. ... lesbiano by Russell McPhee January 23, 2007 0 0 Get merch Get the lesbiano mug. Buy Now — $32.95 See more merch