Used as a substitute for “take it easy pal” or “give it a rest asshole”. It also sounds pretty cool and can spark up some laughter to say it out of the blue. You know how it goes.
Kohl: Kyle let’s go buddy you’re taking for ever
Kyle: Give me a fucking break alright


Kohl: Long time no see Kyle, good to see ya!
Kyle: Give me a fucking break, bro, how’s it going?
by Dr. Malone February 13, 2018
Originated as a response to the emo fagots who constantly feel the need to write and tell everybody about their feelings. If you have a journal, then we're talking to you! But they respond "You don't know how it is" or "You don't know what it's like." I say "Give me a fuckin' break! NOBODY CARES!" Keep it to yourselves, it's not that bad, this means you OWL CITY! Get out of your mama's basement and get some fuckin' sun. The term "Give me a fuckin' break!" has since evolved from this early usage, it now is used as a common response for anyone bitching for no apparent legitimate reason.
Statement- "My life stinks, the world is against me. :("
Response- "Give me a fuckin' break!"

Subject- The movie Twilight.
Response- "Give me a fuckin' break!"

Action- Emo kid wearing jeans tighter than Daisy Duke.
Response- "Give me a fuckin' break!"

The uses for G.M.A.F.B. (Give me a fuckin' break!) are endless!
by Orenthal James June 3, 2010