Phrase used to describe one who has consumed far too much liquor and is therefore reduced to a drooling, snoring, unconcious lump who may or may not end up vomiting on themselves or other people later on in the evening. May sometimes lead to boot and rally, pissing in the fridge, or other drunken acts which will undoubtedly not be remembered in the morning. See ptfo. This is the most opportune time to attempt such daring feats such as teabagging, giving a flying squirrel or other humiliating acts.
Dude, check nick out, Game over.
Woah, did nick just boot-n-rally? i thought it was game over! add another tick to the boot-n-rally tally.
by Ry-Lo September 17, 2007
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1.Something that is Over.
2. A situration that is lost.
3.Nothing left to do.
Man! I lost the match Game Over.
His wife just caught him cheatin."Game Over"
by DE-BO July 5, 2004
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When you finally end it completely... you’re a swallower & even you won’t swallow anymore of their bullshit.
Ohhh... so you like to play games...?

Lol... sorry baby, I was the real deal... don’t wanna play that kinda game . game over.
by java804 March 17, 2018
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when the act of slipping or falling results in fatal or severe bodily harm
dude my brother had a game over in the shower.
omg how?
he totally slipped on the soap and broke his leg.
by NRHsteezy March 5, 2008
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When something doesn't go your way. When a girl is not attrative. When you run out of alchol. When the subject is over.
1.You found out that your ho is pregnant "game over"
2.No way dude, that girl is "game over"
3.No beer? This crack whore party is "game over"
by Crap Weasle October 4, 2004
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When someone's dead, or too messed up to go on living a normal life.
-You hear about Eddie?
-Yeah I heard he od'ed on some bad coke.
-It's game over man.
by david k February 28, 2005
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