When you are into repeated usage of hardcore illegal narcotics. Ex.heroin, crack, coke.
Ooooh...AH AH AH AH COME ON GET DOWN WIT DA SICKNESS!
by Douglas and Manuel November 19, 2002
Get the mug
Get a down with the sickness mug for your Uncle Callisto.
A way for guys to express how they feel about a woman's looks. Usually used to express really ugly women. Its kind of like saying they are really good at looking bad.
Guy 1 - Hey man you have to take one for the team tonight!

Guy 2 - You have to be crazy buddy, those chicks are down with the sickness!!!
by Gamesync November 17, 2008
Get the mug
Get a Down with the sickness mug for your dog Rihanna.