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When you do uppers and downers at the same time, particularly meth and marijuana, but can typically refer to energy drinks as well.
I rolled a bowl and smoked a jank the other day and got crosswired as hell.
by DysFunK Smith February 21, 2010
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Cross wired: The act of getting high and drunk at the same time
Bruh we pounded back 2 26ers of smirnoff ice then we smoked 4 bowls, we were cross wired as fuck!
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