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Deriving from South Arlington VA, it is a rewording of the phrase, "what's good?" which is slang for, "how're things going?". Also a way of asking, "what're you up to?".
Ex. 1)
Steve: Aye yo what's grapes.
Me: Wuz good wit it.
*proceed to dap*

Ex. 3)
Steve: Yo son, what's grapes?
Me: Getting Pollo Rico son.

Ex. 2)
Steve: Yo what's grapes?
Random Person: Fruit? What the fuck?
by Arlingtang May 22, 2012
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