Top definition
When an individual posesses a rather unorthadox gene in ones DNA causing unorthadox actions and manerisms at random intervals.

The U-gene was first discovered in one Nimesh Jani a.k.a Lippifool
Person 1: (shakes head and make unorthadox sounds)

Person 2: YO! your a Ugene!
by annomous December 15, 2007
Get the mug
Get a Ugene mug for your barber Beatrix.
3
A word to describe someone to be a white school shooter
Usually described in a school setting
Hey, did you that Kyle is a Ugene
by BroMomento October 06, 2019
Get the mug
Get a Ugene mug for your barber Beatrix.