The hot cruising street in Wisconsin that passes through several cities and is host to major titties. There are many restraunts and stores on the highway, as well as lots of hot ass.
I'm going out to Highway 100 tonight for racing and titties.
by Jeffious April 24, 2004
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The way parents tell each other they are horny in front of their kids without their kids knowing.
Dad: "Hey Hun, where's the turn off?"
Mom: "Oh mhmm, on highway 69."
Dad: "mhmmm"

Kids: "HUR HUR MOM SAID 69!"
by KingKTheThird June 3, 2013
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The anal cavity; usually used when speaking in a sexual manner about taking it in the ass
Hey look at Adam, he is probably about ready to go down Misty's Hershey Highway again...
by Nilats April 25, 2003
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1. The complete opposite of the Stairway To Heaven

2. An AC/DC classic. I love it.
..."I'm on a Highway to Hell"...
by ACDC FOREVAR!!!111 August 23, 2004
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An awesome Dropkick Murphys song. Also, a euphemism for alcoholism.
Drop me off, sign me in, clean me up and let me out
Man that nurse is a bitch, this sucks, she says my jug ain't allowed
I've had my share of Mt. Pleasant messiahs wearing slippers & robes, trying to bum my smokes
I'm gonna Thorazine shuffle straight out that door
Head to the farm and find me a cure

--Dropkick Murphys "Sunshine Highway"
by A. A. Ron August 13, 2006
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An extended middle finger from a fist thrust forth whilst driving, as a gesture of anger toward the person who it is aimed at.
"that prick is tailgating me. Give him the 'ol highway salute"
by phantomjack December 5, 2006
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when the price for something is sky high, because the manufacturer knows you need it and have no choice but to pay for it. stems from gas stations on highways in the middle of fucking nowhere who charge $10 for a 2 year old microwave burrito because they know the next gas station is 150 miles down the road.
Person 1-"Man, I paid $50 for 3 gallons of gas, a pack of gum, and a soda last night at this gas station in bumfuck Egypt"

Person 2- "Talk about highway robbery!"
by One1ove719 January 31, 2010
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