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The backlash one experiences after a weekend of partying, usually on the designer drug ecstasy, the following tuesday after said weekend.

For reasons not clear, most ecstasy users have a 'hold-over' day in the 24 to 36 hour period following comedown (the ate up period), where the 'down' effects of the drug don't become apparent. This 'hold-over' day usually falls on a Monday if Saturday night was the day of usage. The next day, the Terrible Tuesday itself, is usually a day filled with depressive feelings and overall sadness and malaise. Dealing with critical issues is almost impossible and one is almost guaranteed to have mood swings.

Usage of the supplement 5-htp is recommended along with a bottle of Pedialyte immediately after coming down off of the roll in order to dampen, if not completely neutralize, the depressive effects from the E.

True origins are unknown, but most experts in the subject area agree that the term was probably coined during the ecstasy wave of the 90's and the subsequent rise of EDM (Electronic Dance Music) subculture in America.
Carl: I'm sad, hold me :(

Anne: Well, if you took your 5-htp like I told you too, you wouldn't be crying over those TPS reports. Not eating 7 rolls on Saturday night would have helped as well.

Carl: I want puppies and sunshine, boo hoo hoo :(.
by Socialcommentary2000 May 04, 2005
Happy St. Patties Day!
The 1979 Red River Valley tornado outbreak was a tornado event that occurred on April 10, 1979 near the Red River Valley. It's most noted for the F4 tornado that hit Wichita Falls, Texas and is commonly referred to as "Terrible Tuesday" by many meteorologists. There were five satellite tornadoes spinning around the parent tornado.

If the winds don't die down soon, we're gonna have us another Terrible Tuesday!
by cam408962 April 14, 2009
Happy St. Patties Day!