Getting someone high for the first time who had previously been skeptical or fearful of weed. If you watch the film "The Matrix", you'll see that Morpheus' speech to Neo about taking the Red Pill can apply almost perfectly to that situation.
Chris: Man, Ashley is so anti-weed. Gives me dirty looks if I even try and talk about it.

Sean: Not anymore dude. I smoked her out last night.

Chris: For real? Damn you had her taking the red pill!

Morpheus: "This is your last chance. After this there is no turning back. You take the blue pill, the story ends, you wake up and believe whatever you want to believe. You take the red pill, you stay in Wonderland, and I show you just how deep the rabbit hole goes."
by Hollywood Swinging November 24, 2010
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The act of suddenly or gradually understanding the superiority of the right side of the political spectrum.
This involves truly understanding the physical and metaphysical world in a way that a person on the left side of the political spectrum would normally choose chooses to ignore.
"Hey bro, I've been taking the red pill lately, and I think I finally understand everything. Care to immerse yourself in my right wing literature?."
"Nah bro, I'd rather remain ignorant. Now if you'll excuse me I need to go beat my meat to the Communist Manifesto."
by TheAdamSandler June 12, 2017
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Originating from the movie The Matrix, this colloquial term means to face the hard reality instead of staying inside the comfort zone of fantasy. Synonym of "face it". Antonym of "take the blue pill".
After procrastinating for 5 hours on the Internet, I decided to take the red pill and start the long essay assignment.
by cutesy pastel living doll March 7, 2014
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From the first Matrix movie. Taking the red pill opens the soon-to-be Neo's eyes to the fantasy that he had been living in. Morpheus says to Neo "You have to understand that many people are not ready to be unplugged, and many of them are so inured, so hopelessly dependent on the system that they will fight to protect it."

Contrast with taking the blue pill. If Neo would have taken the blue pill, he would have stayed within the Matrix and been blind to reality.
Morpheus asks pre-Neo Keanu to take the red pill. As Neo reaches for the red pill Morpheus warns Neo "Remember, all I'm offering is the truth. Nothing more."

by Peakey April 6, 2006
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