When a man allows a woman to twist his Scrotum so tightly that the individualtesticles are no longer distinguishable. Typically requires 8-10 complete twists to achieve Testicular Singularity.
Boris: "Hey Jeff, wanna come watch the football game at my house this sunday?"
Jeff: "No thanks Boris! My wife and I will be attempting to achieve Testicular Singularity that day!"
The retarded cousin of Multiple Sclerosis, this disease only affects male genitals, causing complete numbness, leading to permanent, untreatable erectile dysfunction.
Doctor: You've been diagnosed with Singular Sclerosis. You will never be able to pound Zucker's fat, hairy ass again.