A Hanna-Barbera canine cartoon saying for "Uh-oh," beginning with THE JETSONS' Astro (1962) and continuing with Scooby-Doo in the Seventies.

Astro tended to speak a kind of English except that words with beginning consonants were replaced with an "R," and "R" was inserted in front of vowels.

Scooby-Doo was less fluent, but was given "Ruh-roh" as a kind of running gag when things were going bad.

Now "Ruh-roh" is sometimes used as a jocular trope where dogs are concerned, as in a recent news story about a dog who was accidentally released by Air Canada from his cage at the San Francisco airport. Rough meaning: "I goofed" or "I'm in trouble."

Comedy replacement for "uh oh", Scooby Doo style.

Scooby Doo's comedic mispronunciation of "Uh Oh", it is also a play on potentially dire situations, usually starting with a minor event that could escalate into something huge.

expression used in place of "uh oh"
derived from the popular cartoon show, Scooby Doo