A boxing game for the NES. It became in instant classic and is still one of the NES's most famous titles.
I totally just knocked out that flamingo dude without taking a single blow in Punch Out!
by Quizznotik May 14, 2006
greatest boxing game ever developed for the original nintendo
Punch-out?!

Hell Yeah!
by pascaL July 25, 2004
Military slang; when abruptly and decisively aborting a mission or action; to eject out of an aircraft
We've been hit! We've been hit! Mayday, mayday we're going down. Punch out! Punch out!
by Mike T. Hardwarner August 23, 2007
When you're taking a dump and there's an interruption so you have to stop mid-dump and wipe quickly.
I was taking a dump, then heard my favorite song on the radio so I had to quickly punch out.
by ziggymahoney July 24, 2012
When a caller on XM Radio's most popular program, Opie and Anthony on XM202 The Virus, calls in to make a point then leaves abruptly. The caller says 'Punching out' to signify the end of their call.
"Hey b-b-b-boys. The power of Dice compels you, the power of Dice compels you...Punching out."
by grrr,everything's taken October 13, 2008
hey I'm going to punch out than go to bed or did you just get done punching out?
by dirtybrad December 31, 2011