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Primarily for movie goers, the pre-pee is when one goes to the bathroom before getting the movie starts, in order to avoid having to go to the bathroom in the middle of a movie and miss a good part.
(while on premiere line)

A: I heard this movie is dumb long
B: Yeah, 3 hours or something
A: I'm gonna go pre-pee. Hold my spot?
B: Yeah, sure. I'm next though.
pre-pee by secretly June 6, 2007
That little spot of pee that appears when you really have to go to the bathroom and some just sneaks out into your undies.
What the hell, Jane, what's with all those pre-pee stains on your underwear? You have a bladder problem, son?
pre-pee by Ks1994 June 13, 2012
a person who has not peed yet
you lookin like a pre pee ni-
pre pee by breadbiscut October 28, 2021

prepeepoopoopeepoo 

The meaning of having to shit and piss at the same time
Oh man I just prepeepoopoopeepoo everywhere
prepeepoopoopeepoo by Urinate February 8, 2021