When you add someone as a friend on Facebook and they accept your friend request, you poke them just once then delete them as a friend. Good way to get revenge.
Adam: Dude, Grace is really getting on my nerves.
Mike: Then give her a good ol' Poke and Run.
by neergyad May 7, 2009
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to have sex with someone and then run; meaning one of their parents just caught you in the act with their daughter, you claim to have worn a condom when you actually didn't or you're just a douche
Matthew: I was caught having sex with my girlfriend by her dad

Kenneth: Ah, the classic poke 'n run
by speedster55 October 20, 2010
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When someone pokes someone and then runs; they never call again
Dillon and john were haning out.. dillon poked john and run; Poke&run
by Robbbo October 6, 2007
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