In Spanish, and in many Spanish speaking countries, "nene" is a term of endearment used for males ("nena" for females).

It can be used toward each other amongst lovers, family, friends and even sometimes strangers in a joking or "light-hearted" manner, depending on the context and how its used in the Spanish speaking country of origin where the person saying it is from.

It can be equivalent to saying "honey", "hun", "sweetie", "babe", "baby", etc.
Wife: "How was your day at work nene?"
Husband: "Exhausting.. I'm tired and hungry. What's for dinner mami?"

Mom: "Hurry up and get ready for school nene. You're gonna be late!"
Son: "But I don't feel so good. I think I'm sick" *coughs*

Friend (guy): "Damn, look at Carmen.. She's so fly."
Friend (girl): "You still crushin' on her nene? Man, you've liked her since 6th grade! Why don't you just ask her out??"

Cash register older lady: "Find everything in the store ok nene?"
Kid: "Yes Ma'm"
by Mamisonga25 January 24, 2011
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a word a girl uses for her novio. it's like honey or baby.
i love my nene
by gaby June 28, 2004
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The sweetest most gorgeous girl in the world! Friendly to all but keeps your deepest darkest secrets and never tells. Her long beautiful hair, rocking body, and model-like face turns the head of more than a few boys'. Her crazy personality draws many friends. Having a NeNe in your life makes everything perfect!
She's so perfect, she must be a NeNe!
by Frans4Lyf January 6, 2013
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A character from the Pico series. She is a suicidal girl who frequently tries to kill herself over trivial reasons. Nene made her first appearance in Nene’s Interactive Suicide. Since then, she has been portrayed as a love interest and ally to Pico in various flash games and animations.
"I have herpes! I look awful! It looks like there's only one thing I can do! I must die with honor! HARI KARI!!!"

- Nene
by Ava No Last Name September 15, 2022
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Nene : a beautiful female , bout her shit , always there for anyone if needed, she got all the hoes but only want one person , loyal , sweet when she wanna , or mean when she wanna , always the lil sister
by Nene Pooh December 14, 2019
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Nene is a bad bitch that holds her on and she is fearless
Damn she bad her name gotta be nene.
by habits2000 October 8, 2019
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