1)A term used in MMORPG's, meaning the best tank in a massive group who is questing. There responsealbilitys includes building aggro and taking dmg.

2)V: a term using when doing well or dominating in any game.
1)"Bitch I'm main tank i can do whatever i want."

2)"I am main tanking so hard right now. No homo"
by AlfaQup January 6, 2009
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When you absolutely out-Reinhardt the enemy, Main Tank Difference.
Gig: *drops shield*
Super: *hits a huge shatter* MAIN TANK DIFFERENCE
by taafi April 27, 2020
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When one Rein absolutely obliterates the other one until they pop out as a bunch of lego coins
Smurf: gg
super: gg
Smurf: Main Tank Difference
super: do you know who you're talking to?
by Oddballll January 5, 2021
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