To lose a sporting event or game by a humiliatingly lopsided score, especially in an important game or one with national visibility.
( pronounced "emm-ess-yew" )
EX: "How bogus we got crushed so bad by Stanford."
"I know, we totally MSU'd the Rose Bowl."

EX: "I can't believe we made it to the Championship Game. I hope we don't MSU it."
by Spartoon January 02, 2016
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It is a shorter way of saying I miss you. When saying the letters, it sounds like "I miss you"
Person: Aight Imma headout
Me: msu
Person: aww msu too
by sad sad guy July 31, 2019
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