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Japanese has varying levels of politeness - this is the most impolite way of addressing someone. Could roughly translate as "bastard", "scum" etc.
Motoko from Love Hina: Urashima! Kisama wa honto ni chikan desu!

Urashima, you bastard! You're a real pervert.
kisama by Purokku-kun June 14, 2004
Related Words
kisaea kisama Kisaa Kisaee kisaiah Kimaea Kisadeath kisaka Kisanal kisara
The Blue Eyes White Dragon Girl who holds the BEWD in her mind. She appears in the Yugioh Egyption arc and is extremely loyal to Seto, who she cares about deeply and he does likewise. As children, Seto saved Kisara from slave traders. She repaid him by releasing her dragon after the traders sent fire to his village and killed his mother. Years later, Seto stumbles across Kisara again being stoned because of her white skin, blue eyes and white hair. Shadi senses the power within her and Seto takes her back to the palace. His father wanted to test Kisara's power by forcing her to fight in a battle with two more spirits. Kisara, with no idea of her dragon, was helpless. Seto stepped in and saved her, but the two fell into danger, casuing Kisara out of fear for Seto to be hurt, release her dragon and save them both. Later, Seto's father tries to take over Seto's mind by corrupting him with darkness, and Kisara runs to save him. She died taking a blow meant for Seto. After that, his father took over his mind and forced him to fight Atem, the Pharaoh. Kisara saved Seto by destroying his father and promising him that he would never be harmed again. Kisara then intrusts her dragon to Seto. Seto sheds his first tears in front of the BEWD tablet, with Kisara's dead body in his arms.
It is hinted there was a love interest between Kisara and Seto.
"SetoSama, at least I can protect you with the light of my spirit."-Kisara
kisara by Bellebelle3 August 3, 2008
Literally "precious sir" in Japanese ("ki" meaning precious, "sama" being a very polite honorific), it is what a samurai called his enemy. In modern speech, it can be used with someone you want to kill or as an extremely rude insult. Has been used by soldiers and yakuza. Sometimes used liberally by english-speaking otaku.
"kisama!"
"oh no you didn't!"
kisama by spazberry August 23, 2008

Kisaragi Effect 

You don't find it; it finds you.
Derived from a famous original song on YouTube about the Kisaragi Station. The video lacks a title, and so does the channel behind it.
I found an ominous video from an incredibly small channel on my recommendations today. Did anyone else get this Kisaragi Effect?
Kisaragi Effect by Koneka_SDLS January 21, 2022
A loveable asshole, all around funny guy, a complete dick, that one black kid who will finesse you out of yo breakfast
That nigga KiSean took my fuckin breakfast
KiSean by FruityBootyBoyBandits November 25, 2018
Beautiful girl very interesting and a loving sweet hearted very open minded.
Kiseana a loving sweet girl.
Kiseana by Emma herron July 13, 2018