Only when the following two conditions are met: First, a state in one's life were nothing of any importance is happening and no real effort is being put into one's life to change it. Second, a total lack of interest in taking any advice from anyone who would know any better then they do. Usually occuring in women going from there older teens to their adulthoods.
Manny: "How come she seems that she doesn't want to do anything with her life?"
Mark: "No its not that she doesn't want to do anything, shes just suffering from Jessica Syndrome."
by Andres Gonzalez February 9, 2008
Get the Jessica Syndrome mug.
The ailment of being very, very, dumb. Charecterised by random outbursts of an obsurd nature. Some signs may include but are not limited to the following

"Is Peanut Butter Dairy?"
"I always that an autobiography had to do with cars"
"Omg, Earthquake (Picks up cellphone)"
Omg, that gurl tottaly has jessica simpson syndrome, Poor michael.
by Michael F. February 1, 2005
Get the Jessica Simpson Syndrome mug.
Condition of a place or person that seems to attract a large number of murders without having an active part in that crime.

From the TV-show "Murder She Wrote" where every week a close friend or relative of Jessica Fletcher is either murdered or suspected of murder. Suspension of disbelief is stretched to the limit.
I think he killed them all.
Nah, he just suffers from Jessica Fletcher Syndrome.
by Puppy Zwolle April 1, 2011
Get the Jessica Fletcher Syndrome mug.
The "condition" suffered women who are widely regarded by women and gay men as being beautiful and stylish, but are recognized by straight men as being quite homely and totally unappealing.
Madonna is one of several celebrities who suffers from Sarah Jessica Parker Syndrome.
by grandy427 August 27, 2008
Get the Sarah Jessica Parker Syndrome mug.