When someone, usually when gaming, yells and screams at their screen. They're normally loud but doesn't have to be to class as jacksepticeye syndrome. Not to be confused with anything about loving jacksepticeye or being a fan.
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by pseudony.com/index.html January 15, 2017
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I got a case of the Jacksepticeye syndrome. I mean, look how cute he is! I want to fuck his brains out.
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by The British Bostonian November 15, 2016
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