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A competition of one-on-one in any type of situation, sports, fights, tacklezone, etc.
Justin: Paul, i own you in basketball!
Paul: Ok, Justin, ISO right now, i will nut on you.
by EWIED May 22, 2009
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8
1) In "TRON: Legacy", ISO is an acronym for "Isomorphic Algorithm", a life form that spontaneously emerged, without planning, from the conditions that existed in the grid at that time.

2) A term for a really really hot chick. This is adapted from the 2010 film "TRON: Legacy" because Quorra, the last ISO played by Olivia Wilde, is so unbelievably hot.
Guy 1: "Damn, that chick over there is so hot I would let her eat crackers in bed."

Guy2: "Yeah, she's such an ISO."
by Husky Balls December 30, 2010
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10
An acronym for the notable alternative rock band In Search of Sasquatch. Formed in 2010, in the one and only Calgary, Alberta. Consists of four young lads and is soon to be the most commercially successful act in the history of music.
Person A: "Did you see ISOS perform today?"
Person B: "No, I missed it. How was ISOS?"
Person A: "Pretty good if you know what I mean"
Person B: "I'm kidding, I did see ISOS perform"
by lvl5laserlotus December 11, 2012
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11
An abbreviation for specific Asian/English phrasiology, meaning: "I am so..."
Often used, as in, "OH, ISO HORNEY!"
by Richie333 April 07, 2007
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12
n: InSignificant Other. The person that you happen to be with but would rather not.
"I fought with my ISO last night."
"Man, why don't you just dump that bitch?"
by a nony mousey February 11, 2008
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13
An acronym for International Service Organization.
A group of students in foreign language classes involved in providing service to 3rd world countries. Most people join just for the free cookies.
Dakota: Hey Jenna! Are u going to that ISO meeting on Thursday?
Jenna: Yeah! There is gonna be free cookies!!
Dakota: HELLS YESSSS
by Dakots April 07, 2007
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