1)Used by a (usually female) friend to encourage/praise another

2)Sarcastic expression used to mock one who is failing miserably at something/achieving something very insignificant

3)Expression used by camp gay males at any possible opportunity.
1) Janey: I just total betch-slapped that cow.
Joan: You Go, Girl!!

2)Janey threw an empty bottle into the bin from a distance of 10cm.
Crowd: YOU GO GIRL!

3)Dave: Want some coffee?
Mark: You go, girl!
Dave:....is that a yes?
by bedebben aibcadden October 7, 2008
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Phrase of encouragement used by semi-fat chicks that attend an all-womens gym. (or eat Special K breakfast cereal)
An advertisement comes onto the television showing a group of semi-fat chicks laughing, mid-high five with the phrase "You Go Girl" - advertising an all women’s gym, where the cuddly women can feel comfortable.

OR

A Special K advertisement showing a group overweight women on bicycles, laughing and encouraging each other to “push on” – You Go Girl!
by Catfox March 15, 2009
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Network Television adaptation of gay/inner city jargon. While originally meant to be a "hip" way of telling a female friend that she has done the right thing, it has devolved into a moronic cliche used by idiots to sound hip, or by lampooners to underscore just how little respect the networks have for their viewers.
When she told her friends that she had just scored some food stamps the entire group shouted "You go girl!" and "So lets go buy some crack!"
by Not a Democrat April 16, 2003
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hoochie-mama who dances for the pleasure of men (and some women); these women have low self esteem, low pay, and an ass that feels like a pin cushin.. be nice to the brightly colored and feathered go-go girl
that lady who lives down the blook who you often see sneaking to the local theatre
by BruisesOnHerEgo June 1, 2005
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A girl with naturally straight hair that can get her hair wet and still go out. usually a white girl or girl of mixed nature.
by mzshante.com July 24, 2008
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noun A girl who purposely has no fun at a club and c- blocks any man who tries to hit on her girlfriends.Her identifying mark is the term, "we gotta Go." If you dont occupy her she will ruin your chances at meeting her friends.
"Jim im going on the dance floor, youre my wingman so you must cover the we gotta go girl."
by ezekiel1700 January 16, 2010
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