When a woman loses her virginity, the resulting condition that causes an irrational feeling of attachement and love towards her current partner. The severity of this disease should not be underestimated. It can also extend beyond the termination of said relationship. In unusual and rare circustances, it has been known to affect effeminate men as well.
"Wow, he told all her friends he hates her, cheated on her, got with her best friend the day after they broke up, but she is still telling everyone that she wants to be with him, and that he's perfect for her."

"Yeah, that girl is really First-Fuck-Syndromed."
by S.D. and S.W.A. January 31, 2005
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A joke that implies the person will attempt to have sex on the first date with whom they took on the date.
I told her "I fuck on the first date"
by Snicker Tits January 27, 2009
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When you realize after many years from the first sex, that you are best friends.

No necessarily you dated or married, or even had more sex.

You are just first fuck friends ever.
They are first fuck friends ever.

She is mine first friend fuck ever.
by AnotherMiller August 12, 2021
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The precursor of Sloppy Seconds: When a man creampies an individual first with the intention being that said individual is destined to shortly thereafter be creampied again at least once, or multiple times by competing ejaculators.
I'll attend the creampie gangbang as long as I get fuck 'em firsts.
by AmadeuS469 October 25, 2023
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