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when you are out with a group of friends, this is the guy who always fucks things up. Like when you put antibiotic ointment on a cut and fly gets stuck in it, you say "fuck!"
For example, charlie is a fly in the ointment,

tom: " the guys are getting together tonight, wanna come?"

Charlie: " yea!"

Charlie then shows up with his girlfriend
by d-c August 12, 2007
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