when your ass gets sore from sitting for extended periods of time in an uncomfortable seat (e.g. metal folding chairs or bleechers)
I went to see the Chicago Cubs play, the game lasted almost four hours, when the game was over I had some major ass fatigue.
by Michael_Hunt July 5, 2009
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I haven't updated my Facebook profile in months. I have facebook fatigue.
by circushead March 7, 2008
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Being too exhausted on Friday due the rest of the week to go out and have fun, or do anything other than sleep. A serious condition any place where employees or students are worked to the bone.
Suzy: Hey May, our finals are finally over! Its Friday, lets go out and celebrate.
May: I really want to, but I'm running on 4 hours of sleep, I won't be able to make it.

May has Friday fatigue.

Bill: Bob, you won your first case! Lets go out and celebrate, its Friday!
Bob: I've been too stressed out to sleep all week, I think I'm just going to stay in tonight.

Bob has Friday fatigue.
by JStech November 20, 2012
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When you spend too much time coding and are unable to function like a regular human being afterwards. Side effects include: inability to understand social situations, walking like a zombie, and only being able to think about the console.log that you forgot to take out.
After hours of looking at VSCode, Joe was suffering from code fatigue and was unable to arise from his chair and make dinner.
by canyousmellwhtthetrumpiscookin February 28, 2019
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Becoming desensitized to porn after watching/reading too much of it.
Jim had been surfing his favourite porn sites but began to suffer from porn fatigue after a couple of hours.
by caughtthegayhavewe? December 24, 2009
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The fatigue felt after STANDING around and doing nothing while your girlfriend is shopping in store after store.
Oh man! I have such bad mall fatigue after after spending quality time with the girlfriend
by CLiff LEe December 8, 2007
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Going to see a movie, and having to sit through so many commercials and trailers, you're either too tired-out or have lost all patience and don't feel like watching the goddamn movie anymore.
Phil: "How was the movie?"

Andrew: "I dunno... left before it began and got a refund because I got major trailer fatigue after sitting through 30 minutes of previews and the film still hadn't started yet."
by TeddyStix July 8, 2015
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