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1. A brand of beer (or malt liquor) with an alcohol content of about 8%. Usually favoured by people with low incomes, because of the high alcohol content and cheapness.

2. A .45 single action revolver, made by Colt's Manufacturing Company.

3. An alternate name to the song "Crazy Rap" by Afroman.
No money? That's okay, we can drink Colt 45!

Remember to cock the hammer of that Colt .45

Colt 45, and two zig zags, baby that's all we need...
Colt 45 by Kieta October 14, 2007
An efficient means to getting rid of aggravtions.
Feeling kinda down? Down a Colt 45.

Cat pissing on your car tires? Draw your Colt 45.
colt 45 by Lars Sandman December 24, 2008
its kind of like a liquored up beer that sneaks up on you all of a sudden
guy on plane: can you explain these
flight attendant: well colt 45 is like a liquored up beer that sneaks up on you all of a sudden

from soul plane
colt 45 by zach s. August 11, 2005
A song by Afroman.
A .45 caliber gun
A liquored beer
Dude:Yo man you ever here that song Colt 45?
Dude 2:Yea i love that shit

Dude:Check out my Colt 45!
Dude 2:Nice man

Dude:You ever try a Colt 45?
Dude 2:Yea but it's not for me
Colt 45 by i forgots December 22, 2008
Yeah me and my dudes are listing to Colt 45.
Goodtimes Brah
colt 45 by Catheryn March 7, 2008
A malt liquor beverage that gets u drunk quick! Also the best song by Afroman
"Man, gimme summa that colt 45!"
Colt 45 by LeHgs April 10, 2005