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The esteemed school known as St. Francis University. Named after the valiant Catholic priest Saint Arthur Francis, STFU is dedicated to providing their students a quality, yet spiritual education. In addition to the superb education offered at STFU, they are also known for their outstanding basketball team. Their mascot is the fabled Unicorn, as students can be seen all around the campus holding a hand to their forehead and pronouncing "UNICORNS!!!!" to the rest of the world.
1. "S--T--F--U--S-T-F-U-UNICORNS FIGHT!!!"
2. BAM!!! I just Unicorn stabbed you with my horn.
3. "Oh yeah I remember STFU, they had a good basketball team." - Mr. OL
STFU by skyguy86 March 23, 2009
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One would say it while losing an argument or after being insulted; usually used by french speaking canadians.

ESTI FUCK YOU
STFU by oqk January 13, 2011
the definition of stfu is Save The Flying Unicorns, used to make someone shut the fuck up by using confusion.
can you please (go) stfu/ save the flying unicorns (for me) ?
stfu by xXx_anonymous69_xXx August 15, 2016
Stfu is usually short hand for SHUT THE FUCK UP!! But in other , more uncommon cases it means:

SAVING TURKEYS FROM UNICORNS - D-CHIP! ^ ___ ^

Or

Seven Thursdays From sUnday
Anon: What should we call our band?
Mudkip: Kicking Wood w/ Not Politically Correct Folk Singers.
Anon: OH Lol'd. No we gotta make it epic!
Mudkip: STFU?
Anon: lol wut?
Mudkip: Saving Turkeys From Unicorns.
Seaking: FUCK YEAH!!
STFU by Wings of Lead February 1, 2008
"SHUT THE FUCK UP", commonly used to blatantly intimate that someone is being annoying.
STFU by Kevin says STFU April 9, 2006
STFU= Shut The Fuck Up

When you want someone to keep quiet but can't say it aloud because you are out in public or your parents or your boss is there.
My girlfriend was annoying everybody with her constant meaningless chatter. Finally, I turned to her and said, "Jean, STFU."

I was walking down the street when the dogs behind the fence started to bark. I yelled, "STFU, STFU."
STFU - Swim to france, ugly.

Often used when you want an ugly person to remove themselves from your view, subject to failure if used in france.
guy 1: STFU n00b
guy 2: but I can't swim.
STFU by Kinky pinky April 4, 2005