to reduce to utter ruin or nonexistence; destroy utterly; to molliwhop something real nice
After the Mark made a comment about Sean's sister, Sean defenestrated him. Mark was last seen missing two teeth and with a nice shiner.
by Soheil Saeed February 26, 2008
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A fairly adaptive solution for many of society's problems. Consists of turning an otherwise mundane defenestration into a public spectacle, visible to all. Great for cowing the masses back into line with the fear of being tossed out a really high window.

Emperor Cuzco was particularly famous for employing this technique.
"I'm sorry, you've thrown off the Emperor's groove."

*whoosh*

"Sooooorrrrrryyyy...!"
by The Lemon Merchant December 1, 2004
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The act of surgically(professionally or otherwise) sealing the fenestrates of a person or animal's skull.
I've had enough of your shit, man. Shut up before I surgically defenestrate your skull.
by Zatharus July 28, 2009
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The act of uninstalling a Microsoft operating system on a dual-boot PC, thus throwing the windows out of the computer.
"Man, that 'Boot Camp' utility wasn't all that it was cracked up to be. I think it's time for some inverse defenestration on this computer pronto."
by seanparkerfilms July 29, 2009
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c'mon man. defenestrate babies. throwkids out windows. all ugly asf.
go defenestrate babies
by whorenotfound February 26, 2021
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The act of releasing fecal matter through the uterus of the vagina.
My mother has been having severe Guatemalan Pussy Defenestration.”
by Fucking Karen August 21, 2022
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