Sis

Used to be sassy, sarcastic, SIS.
Sis is just such a cute word!!!

Sis-

Sis- NO
Sis that's so cute!

by t_xo88 September 27, 2020

Sis

Ur BEST girly friend in the whole frickin world!!!!!

Hey sis!

by Noney the pony May 21, 2021

sis

the word that avery got sibling-zoned by

avery: he called me sis. i've literally lost sleep over this. what does it mean :(
noah: you just got sibling-zoned

by nopo2 November 06, 2022

Sis

A acronym for "she is self".

Look at her, sis is beautiful. Which means when you speak of Sis, Sis is yourself. It speaks on how you think and feel of yourself. Positive or negative. Talk to her nice 😘

by M. Divine May 05, 2019

sis

So It Seems

Given photographic evidence it appears that the parties in question where somewhat aloof, or SIS...
(an abbreviation for social media eg. Twitter)

by Asgard December 22, 2016

Sis

Term used among gay bottoms that have a double meaning of both “sister” and or “sissy” but used with endearment .

Hey sis how was your night …

Sis it was long and hard

by LuiLifestyle April 05, 2022

sis

Used to show James Charles’ hq yeet language. Expresses love 😌 and hate ❌.

Me: hey boo
Friend: heyyyy *winks*
Me: bihh dont wink at me sis

by sissysnapped January 01, 2019