to tell somebody that they do not know what they are talking about or are just plain irritating
Jord: "I like The Beatles"
James: "I know!!! Shut up Jord!!!"
Tom: " Yeah Jord, shut up!!!" *Tom slaps Jord round the back of the head*
by James Stone December 3, 2006
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An impolite and unghetto way to tell someone to shut their yap or they'll be stole in the jaw. Typically effective, yet more so when a 't' is added to the end. (Shut Up T)
Alex: Yo, that girl is fly, I'ma gonna go get me some of that.

Adelyn: Shut-up, no girl wants your ugly ass self, your lucky you got me.
by og loc February 20, 2005
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Shut your mouth beau
You're supposed to be a PhD holder
Not a screw up stalking people and sitting on urban dictionary writing stupid definitions

What is your problem
You need a good fucking backhand slap to your face with my left foot
Don't waste your life Doc
Put your life to better use than being a cunt

S
Shut up and eat some fucking humblepie
by PurpleStarr January 29, 2019
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in a fight someone will yell out "shut up or run up"! which means shut up and dont fight like a (pussy) or run up and fight like a man!
man you better (shut up or run up)! quick!
by sulaimaan December 18, 2007
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Usually considered 'rude' used to tell someone to be quite. Sometimes, shut up is used to express amazement, even if the person it is being directed to is not talking.
"Shut up Meg."

-Peter Griffin

or
"Shut up!"
"I didn't say anything..."
by modern wards June 24, 2016
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