1. When a person overreacts to a
trifling insult or barb, or to a joke.
2. When someone acts in an
anal-retentive manner, and makes a big fuss out of a relatively
minor problem.
1.
Don't get you're panties all in a bunch, he doesn't mean it.
2. It's not that big of a problem,
don't get your panties all in a bunch, it's going to be
okay.