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down syndrome 

a chromosomal (big word for smart people) disorder which effects someone for they're whole life. They have swollen looking eyes and difficulty with learning. they can also be insanely strong, i know a little girl with down syndrome, she is 9 and she can push an 80kg man to the ground. no problems. good thing is, they are very very nice people and generally more fun and outgoing than most of the nerds who will read this XD.

in short, if you call someone who did something stupid 'a downy' or 'down syndrome' you obviously don't know anyone who has it or have ever properly met someone who has it.
me: my little brother has down syndrome, what do u think of that?

normal person: id like to meet him, i don't know what to make of people with DS.

me: not many people do, you will love him. think jim carrey, just 11 and shorter

normal person: haha sounds good =)
down syndrome by DS Rep. August 3, 2008

down syndrome wombat 

A person who is both ugly as fuck and stupid as fuck. There is no hope of a future for this person

Churchhill Down Syndrome 

Closely related to the birth defect Down Syndrome. Which those with the condition have a widely recognized appearance. Churchhill Down Syndrome cause those with the defect to develop horse face. Symptoms vary from person to person and can range from mild to severe. Long face, buggly eyes, and protruding gums and teeth are typical signs of Churchhill Down Syndrome.
Sarah jessica Parker, Celine Dion, and Tori Spelling are examples of celebrities who suffer with Churchhill Down Syndrome.

Post traumatic down syndrome 

Post traumatic down syndrome - a condition that mimicks down syndrome that is directly caused by Trauma.

Maple Syrup Downs' Syndrome Baby 

The spawn of two mentally-handicapped people who engage in passionate sex, then pass out, to wake up and find they have created offspring. In an effort to preserve the baby until a later date upon which they would be more suitable parents, the child is placed into a large beaker full of maple syrup. The babies are then usually apprehended by law enforcement and sold to chinese dining establishments and served as "pork" in House Special Fried Rice.
Holy Shit, my dad told me that I just ate a Maple Syrup Downs' Syndrome Baby!

Upside Down syndrome 

The disorder in which a person's Down syndrome is so severe that his face is completely rotated out of proportion. More severe cases can affect muscle girth, especially in the forearms. This renders the victim's forearms indistingiushable from pencils. One's speech may also become unamusing and trite.
Chris Max, what's up with your face?
Max BABABABAABaabaaba!!!
Chris O, you must have Upside Down syndrome, which renders yours forearms indistingiushable from pencils. My bad.
Upside Down syndrome by max_fisk December 15, 2008