The second uno reverse is meant to counter an uno reverse, thereby breaking quantum physics laws, ending the world as we know it.
Brad: ur mom is fat
Lawrence: uno reverse
Brad: Second uno reverse
Lawrence: *dies from laws of quantum physics being broken*
Lawrence: uno reverse
Brad: Second uno reverse
Lawrence: *dies from laws of quantum physics being broken*
by Hazodaki October 2, 2022

A card game that destroys friendships and crushes dreams. When lost, all shame and embarrassment will wash upon your soul, thus leading to ultimate anger. The Uno Reverse Card is a different story.
"Did you hear that Carl lost a game of Uno? What a loser."
"I just lost a game of Uno. I shall never show my face upon you again."
"I just lost a game of Uno. I shall never show my face upon you again."
by Clawdeen January 23, 2020

by The real devil's uno April 16, 2021

The Uno reverse card meme trend began around May 10, 2018 when a user linked Uno to the existing "No U" meme. It was a natural fit given that "No U" is an anagram of "Uno." From there, users on the Internet transformed the "No U" Uno card meme into the Uno reverse card meme and hilarity ensued.
by JasonHW November 8, 2021
