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Two Chromosomes Short of Hillbilly

Used to describe someone who looks as if they possess lower than average intelligence can be male or female of any age – usually found in clapped out Novas around McDonalds car parks and council estates. Can be combined with many other insults -

WARNING – If using insult directly to face – please remember they will not understand the word chromosome – or the word two –

See mouth breather
“Christ! – Look at the mouth breather in the Elisabeth Duke Clown necklace – she looks two chromosomes short of hillbilly”
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a few tacos short of a combo platter 

someone who is mentally not with it...looney, lacking intelligence or just plain crazy.
yeah, you could say Jane was not the brightest bulb in the box, her elevator didn't go to the top floor, she is a few tacos short of a combo platter.

two cans short of a six pack

adj. stupid or crazy; not "all there."
oh man, look at this two cans short of a six pack

Few Cards Short of a Full Deck

Refers to a person without snap or intellegence, i. e. their brain does not function as a normal person's would.
Why did your brother put his penis in the hot tub jet again?

Oh, he's got a few cards short of a full deck.

One fry short of a happy meal. 

Nutty, Crazy, Simple, Retarded,

One card short of a full deck
That was an unbelievable, amazing and really stupid thing he did. He must be "One fry short of a happy meal."

That guy is not all there, think he must be "One fry short of a happy meal."

few beers short of a carton 

Used to describe a person with a low braincell count.
That dude is seriously a few beers short of a carton.

two tacos short of a combo platter 

"Man.. that guy's two tacos short of a combo platter!"