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This site, in my opinion is one of the main reasons to why the furry fandom is hated. Literally. The owner is a zoo by the way, which is just so fucking awful.
Weird furry : yo do you know about e621?

Furry : yes?
Weird furry : i jack off to it
Furry : what the hell
e621 by nikon777 September 19, 2023
Related Words
e621 is a public furry pornography site.
Don't go onto e621 unless you're willing to be traumatized and a half.
Samuel: "What is e621?"
Gordon: "Oh god, you don't want to know."

E621.net 

A large online community of furries (and others but mostly furries) that contains SFW art and tonnes of NSFW art.
Guy 1: Yo, did you check my post on E621.net yesterday?
Guy 2: Yeh, cool man.
E621.net by lyricalpaws July 31, 2016

e621.net 

A sin.
e621.net is a sin.
e621.net by $4Life October 6, 2016

Dell Latitude E6210 

A made-up laptop that is an urban legend among furry tech support workers due to the model number being very similar to the website URL of e621.net
person 1: Did you hear about the Dell Latitude E6210?
person 2: No, but it sounds rather cursed. I don't even think it exists.