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Leona syndrome 

When a support player (Typically playing Leona) in the game league of legends starts many bad fights or just goes in 1v5, either throwing the game or losing harder, usually followed by blaming teammates for not following on the bad engage.
Mid lander: Why is Leona 0/10 at 15 min?

ADC: She’s got Leona syndrome
Leona syndrome by SKTbronze July 6, 2020

Keefy Syndrome 

The act of liking someone/thinking they like you after having only exchanging a of couple words with each other. Extreme cases include no words been said but instead just them staring at you for around a second, enough for you to fall in love with them or for you to think they love you.
Person 1: I’m in love with that girl from maths I’d do anything for her to be my gf.

Person 2: Why?

Person 1: When I was leaving class she asked me if we have any homework due tomorrow when she could of asked anyone.

Person 2: Man you’ve got extreme Keefy syndrome she don’t like you she got a bf plus why would she like you fat fucking shit get a life you cunt.
Keefy Syndrome by Josephgeorge12 December 10, 2022

Hoppean Syndrome 

Hoppean Syndrome is any unusual bowel movement, which was originally caused by the consumption of the highly dangerous Hoppean Bar. It has now evolved into any unusual bowel movement.
He's been in the toilet for an hour now, he's got Hoppean Syndrome.

Restless Groove Syndrome 

Restless Groove Syndrome, or RGS, is a disease suffered by 90% of americans and 75% of people world-wide.
Common symptoms include moving a body part in-beat with music that is currently being listened to, such as tapping of the foot or banging of the head.
There are no current cures for RGS.
Cool Kid One: Look at that metalhead! what's wrong with him, and why is he moving his head so rapidly!?!?

Cool Kid Two: It's apparent that he suffers from Restless Groove Syndrome.

Approaching Doom Syndrome  

When you get a chill down your spine and the feeling that someone is about to get you. 50% of the time this means you are about to get the shit kicked out of you.
“What is this Santa Claus person, and how do I find him?”
"why?"
"Im going to kill him."

Somewhere on earth, Saint Nicolas shivered from sudden Approaching Doom Syndrome

Poser's spark syndrome

a person who poses as many different faces. One day they could be a Nazi, the next day a wanna-be gangbanger. The could be emo but sorta "spark" up to be a Prep.
This is known as Poser's spark syndrome.
Man, he's so lost. He doesn't know who he is anymore. Yesterday he wanted all the Jews dead, today he's got a bandanna andd sagging pants.

Yep. He's got Poser's spark syndrome.