scissor-sister Share definition Flag The female version of a butt-buddy. Two female friends who spend time with each other in excessive amounts. Jill and Sara spend so much time with each other that they're scissor-sister(s)! scissor-sister by John Clarkersoner April 23, 2010 0 0 Get merch Get the scissor-sister mug. Buy Now — $32.95 See more merch