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Not "all there in the head"; possibly lacking intelligence or common sense. The wall-eyed background character in "My Little Pony: Friendship is Magic", Derpy Hooves, is named after this.
Hey, look at that guy sticking his aluminum foil-wrapped dick into an electrical outlet. That's derpy if I've ever seen it.

Derpy is best pony.
derpy by datSato January 3, 2012
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A pony that is from My Little Pony
I watched My Little Pony and my favorite pony is Derpy
Derpy by Cat Lover50 December 9, 2015
The name of a female, greyish, winged, yellow-maned Pegasus pony from Equestria and the My Little Pony world.
Derpy lives in Ponyville and her favorite food is muffins.
Derpy by Newmarduk November 1, 2017
Too stupid to move
Wow, you are so derpy
Derpy by Lily Billy December 1, 2016
When someone or something is really weird.
¨Omg that bird looks so derpy¨
Derpy by purpleyderply October 20, 2016
Looking slightly retarded in a picture
"She looks so derpy with that duck face!"
"That guy looks so derpy in his pictures."
Derpy by lilstrudel May 21, 2012
To be inefficient, slow, unable, inexperienced, not working correctly, stupid, naive, etc. A word that usually takes the place of "retarded."

Can be pertaining to a person or a thing.
I tried to send my essay in via email last night, but my computer was being derpy.

*Friend trips and falls over own feet
You are so derpy sometimes
Derpy by Derpyhoovs July 28, 2011