A retarted ass dog named duke that has 3 missing chromosomes and likes dick up his ass and having cats shoved up his ass
by Retartedmonkey August 16, 2023

"Down syndrome ass" is a colloquial term used to describe a buttocks that appears larger or differently shaped than typical. It's often characterized by a notable prominence or awkwardness in its form, resembling the appearance associated with Down syndrome, a genetic disorder. This term is not medically or scientifically recognized and can be considered offensive due to its derogatory nature.
"Yo, check out Shawty over there with that Down syndrome ass, it's like two basketballs stuffed in her jeans, no lie."
"Yeah, she got that Down syndrome ass, it's like she's carrying a whole extra load back there, making heads turn on the block."
Bro, her booty's like 'bam!' – Down syndrome ass, making the hood go wild, you feel me?"
"Yeah, she got that Down syndrome ass, it's like she's carrying a whole extra load back there, making heads turn on the block."
Bro, her booty's like 'bam!' – Down syndrome ass, making the hood go wild, you feel me?"
by Brained February 7, 2024

by autistic cancer downs boy March 9, 2017

Someone with an extra chromosome
by Illegal border hopper April 21, 2022

FaZe Down syndrome is when a fan of the Call of Duty league franchise "Atlanta FaZe" becomes so obsessed with the team that all logic flies out the window
Symptoms include:
Agreeing with everything a faze player says
Making awful excuses about why faze lost a game (eg. "It was Rigged!")
Arguing with anyone on twitter who says faze isn't the best
That guy over there thinks simp is greater than Scump he obviously has FaZe Down Syndrome
Agreeing with everything a faze player says
Making awful excuses about why faze lost a game (eg. "It was Rigged!")
Arguing with anyone on twitter who says faze isn't the best
That guy over there thinks simp is greater than Scump he obviously has FaZe Down Syndrome
by Realistic faze fab January 21, 2023

Condition where someone moves to Hackney, grows stupid facial hair, starts wearing braces and woolly hats and riding a fixie retro bicycle, turns Vegan suddenly and decorates their home with overpriced unwanted furniture and recycled pallets. Even buys a turntable.
Since Colin moved to Dalston, he’s turned into a right wanker. That guys got a serious case of Hackney Downs Syndrome.
by Blah wars September 30, 2018

when you have all the chromosones
by boudaciousslayqueen420 June 9, 2022
