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Thalidomide

Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy.3 While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus.3 It is administered orally.

Common side effects include sleepiness, rash, and dizziness.3 Severe side effects include tumor lysis syndrome, blood clots, and peripheral neuropathy.4 Use in pregnancy may harm the fetus, including resulting in malformation of the limbs.3 In males who are taking the medication, contraception is essential if a partner could become pregnant.4 It is an immunomodulatory medication and works by a number of mechanisms, including stimulating T cells and decreasing TNF-α production.3
Thalidomide was first marketed in 1957 in West Germany, where it was available over the counter.56 When first released, thalidomide was promoted for anxiety, trouble sleeping, "tension", and morning sickness.67 While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose in 1961, and the medication was removed from the market in Europe that year.65 The total number of embryos affected by use during pregnancy is estimated at 10,000, of which about 40% died around the time of birth.63 Those who survived had limb, eye, urinary tract, and heart problems.5 Its initial entry into the US market was prevented by Frances Kelsey at the FDA.7 The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries.75

It was approved for medical use in the United States in 1998.3 It is on the World Health Organization's List of Essential Medicines.8 It is available as a generic medication.4
by Bad C dev July 25, 2021
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Thaashviny is like an angel
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Thalapathy

There are two Thalapathies. One is MK stalin and the other one is an Tamil actor who loves to stole others title and branded himself as well is Joseph Vijay.

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Thalapathy

Virat Kohli is regarded as thalapathy in india. There is one more low budget thayoli hailed as thalapathy by his thevangus in TN. But Virat Kohli is the real thalapathy
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by BHAIRAVAA October 18, 2021
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talshiar

Don't let the talshiar catch you.
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Thalia

Thalia is the most gorgeous person you’ll ever meet. She only aceepts some people in her life, but once you’ve been accepted. She’ll love you forever.
Is that thalia?

sure is
by Zodiacx May 3, 2020
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