Someone who has exceptional knowledge on all things "trippy"
Ashley: Wow, Carly, you sure are a drug wiz!
Carly: I know! Ectasy is my middle name!
by Melonella November 14, 2008
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When the typical marijuana effects (indica and sativa), affect you in reverse. The commonly known Indica or "in the couch" actually makes you more uplifted and up like Wiz Khalifa. And a sativa may make you more sleepy and have a greater munchies sensation.
"There's no better kind, whether sativa or indica. It just depends on your chemical makeup, who you are. Some people smoke sativa and feel more up and smoke indica and feel more down. I'm the type of the person where I smoke indica and feel way more up and smoke sativa and feel down. That's the opposite of what happens for most people." - Wiz to Esquire

Yo man why'd you pick up indica weed, it's day time?

Sorry bro I have Wiz Khalifa Syndrome. Indicas actually gets my creative juices flowing.
by Pudge Rodriguez August 11, 2018
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Cheez wiz spread on a toasted bagel. Originally invented by JGB circa 1980's.
What do you want for lunch?

I'll have wiz on a T'd bagel, please.
by The "Big Guy" Brown January 28, 2019
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To trick one in such a fashion that the person on the recieving end has to stop and think at a later time: "What just happened here?". To leave one in the state of dumbfoundedness through any sort of tomfoolery.
After The Kid and his crew left the local sport store, the cashier wondered how they could buy a $500 golf club for $15.86.
by Anthony Fratto March 27, 2003
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To trick in a sly and underhanded fashion; to confuse someone to the extent that they have no clue what just went on.
After losing all his money in the Video Poker Machines, Hollywood wizz wazzled the kitty on the bar for two bits.
by Johnny Fontaine March 27, 2003
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when your really surprised and shocked.
caitlin: omg did you hear about alice shes a slag 5 boys in 5 days she now has chlamydia

abii: jee wiz skunk master flunk
by 123456789swagcool December 5, 2017
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